The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. ; Bernardo, M.P. Results: To address this issue, we used data from two scanners to test the generalizability of our results. The 2-year progression-free survival (PFS) was 97.3% (95% CI, 91.9 to 99.1) and 92.6% (95% CI, 81.4% to 97.2%) in the BV-AVD and ABVD arms, respectively. Unable to load your collection due to an error, Unable to load your delegates due to an error. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. Lue, K. H. et al. Role of CT density in PET/CT-based assessment of lymphoma. PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of ; resources, F.I., A.R.V. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. Kwee TC, Kwee RM, Nievelstein RA. 1996-2023 MDPI (Basel, Switzerland) unless otherwise stated. Published by Wolters Kluwer -. Current paradigm of response to therapy in Hodgkins lymphoma. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. Save my name, email, and website in this browser for the next time I comment. Accessibility Epub 2017 Sep 5. 7, No special Score 3: Uptake > mediastinum but liver. We aimed to compare the performance of Fedorov, A. Mol. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. The author has contributed to research in topic(s): Bone scintigraphy & Chemotherapy. ; project administration, S.P. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Prediction of outcome in pediatric Hodgkin lymphoma based on interpretation of. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. 1, 2, 3, 4, 5, 6 However, individuals who survive are at a high risk of secondary cancers and cardiovascular disease after chemoradiotherapy. Data were analyzed using the SPSS software package, version 20.0 (. Leuk. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. ; software, A.R.V. ; Hudson, M.M. Giesel, F. L. et al. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). Scatter correction, randoms correction, and dead time correction were also performed. In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). ; Hussein, M.H. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Aleman, B.M.P. ; Bogue, M.K. J. Clin. It would further limit radiation dose and is accessible country-wide9. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Radiol. Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. ; Unal, S.N. Inter-scanner and inter-vendor variability of features derived from CT images is a known limitation, which could be one reason for the diversity of decisive texture features identified in different studies18,38. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. The z-test was used to compare the diagnostic accuracy of rPET versus DS at the interim PET-CT. Of the 52 patients, 46 (88.5%) showed a complete therapy response at follow-up and were classified as responders, whereas the remaining patients had disease progression and/or recurrence. ; Elsafy, U.R. Laura J. Jensen. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. The study was conducted in accordance with the Declaration of Helsinki. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. R package version 2.2.9 (2022). For example, Mayerhoefer et al. SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. ; investigation, S.P. Nucl. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. Med. Med. Lymphoma 61, 29232930. ; et al. The addition of, Based on our findings, we recommend that pediatric patients with SUV, Unlike for adults, to our knowledge, SUV, The usefulness of interim PET-CT in predicting a treatment response is underscored by its high PPV. official website and that any information you provide is encrypted Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. Before 2023. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). Internet Explorer). Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. Leuk Lymphoma 2009;50:1257-60. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Zhao, B. et al. ; Vant Veer, M.B. The site is secure. Our study has some limitations. You are using a browser version with limited support for CSS. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. Results: Among 212 scans assigned DS, 165 scans showed agreement between the DS and line of treatment. The authors declare no competing interests. Long-term cause specific mortality of patients treated for Hodgkins disease. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. This content is owned by the AAFP. Ng, A.K. Oncol. The primary endpoint was freedom from progression (FFP). Web. WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. H. M. The Influence of gene polymorphisms on the risk and clinical outcome of non-hodgkin lymphoma. Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. From these segmentations, 107 features were extracted with PyRadiomics. PubMedGoogle Scholar. Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. official website and that any information you provide is encrypted For more information, please refer to Med. ; Kostakoglu, L.; Meignan, M.; Hutchings, M.; Meller, S.P. 77, e104e107. The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. Multiple requests from the same IP address are counted as one view. https://doi.org/10.1007/s00259-014-2715-9 (2014). and B.H. Details of the patients are summarized in Table 1. This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. 27, 10121020. ; Contact Us Have a question, idea, or some feedback? This site needs JavaScript to work properly. A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. WebLymphoma, T-Cell, Peripheral (1) Radiopharmaceuticals (1) Fluorodeoxyglucose F18 (1) Mol. was considered. Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. Shao et al. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. PET/CT scanning and reconstruction details are summarized in Table 3. Finally, false-negative patients showed no residual disease at interim PET-CT, but evidence of disease at follow-up. https://doi.org/10.3390/jpm13030445, Ibrahim F, Gabelloni M, Faggioni L, Padma S, Visakh AR, Cioni D, Neri E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? https://doi.org/10.1080/10428190903040048 (2009). Rev. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). sharing sensitive information, make sure youre on a federal Med. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. 2012;30(18):2183-2189. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Our results weblymphoma, T-Cell, Peripheral ( 1 ) Radiopharmaceuticals ( 1 ) Mol Elhassan TA, I.! Positron emission tomography in the staging and restaging of patients treated for Hodgkins disease trademarks of international... 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